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June 20, 2026American Journal of Hematology

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network ( EMN )

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Authors

HLHeinz LudwigETEvangelos TerposFGFrancesca Gay

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Overview

Systematic review and network meta-analysis reveal therapy impacts progression-free and overall survival in newly diagnosed multiple myeloma patients.

Key Points

  • This review aims to analyze the effects of maintenance therapies on progression-free and overall survival in newly diagnosed multiple myeloma patients.
  • Conducted a comprehensive systematic review of maintenance therapy studies
  • Aggregated data through meta- and network meta-analyses
  • Evaluated therapeutic regimens including lenalidomide, proteasome inhibitors, and CD38 antibodies.
  • Daratumumab–lenalidomide showed the highest progression-free survival benefit compared to observation.
  • Overall survival benefit was significant with lenalidomide alone in transplant-eligible patients (TE).
  • CD38 therapy trended towards improved overall survival, unlike proteasome inhibitors.

Cite This Study

Ludwig et al. (2026) studied this question.

synapsesocial.com/papers/6a362f92db0793dc1a53707fhttps://doi.org/10.1002/ajh.70397
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