Narrative review synthesizes mechanisms and challenges of MSC therapies in preeclampsia, suggesting future directions.
Key Points
The aim is to explore the therapeutic potential of mesenchymal stem cells and their extracellular vesicles in addressing preeclampsia and its associated pathologies.
Narrative review synthesizing evidence from in vitro studies and in vivo rodent models.
Focus on mechanisms such as trophoblast behavior modulation and vascular homeostasis restoration.
Identification of translational challenges such as source heterogeneity and safety concerns.
MSC-derived small extracellular vesicles show potential in mitigating preeclampsia pathology.
Critical mechanisms include modulation of VEGF/sFlt-1/PlGF axis and oxidative stress attenuation.
Need for standardized manufacturing protocols and safety evaluations has been highlighted.