Randomized trial identifies HDHD3 and HMG20B as candidate genes for temporomandibular joint osteoarthritis, suggesting pathways for treatment.
Key Points
The study aims to identify potential therapeutic targets for temporomandibular joint osteoarthritis using multi-omics data and experimental validation.
Integrated analysis of eQTL, pQTL, and mQTL data with GWAS summary statistics
Mendelian Randomization and colocalization analyses to explore gene causality
Experimental validation using a rat forced mandibular retrusion model.
HDHD3 and HMG20B were prioritized as candidate genes associated with TMJ OA
Transcriptomic validation indicated that HDHD3 is significantly upregulated in affected groups (p < 0.05)
Folic acid identified as a candidate compound through drug prediction and molecular docking.