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June 20, 2026NutrientsOpen Access

Beyond Early Initiation: Predictors of Successful Early Enteral Nutrition Advancement in Critically Ill Patients

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Authors

JCJungwon ChoASAhreum ShinCIChami Im

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Overview

Retrospective cohort study investigates predictors of early enteral nutrition advancement in critically ill patients, indicating tailored interventions are needed.

Key Points

  • This study aims to identify clinical predictors of early enteral nutrition initiation and advancement in critically ill patients upon ICU admission.
  • Retrospective cohort study involving 2112 critically ill adults receiving enteral nutrition from January 2020 to December 2024
  • Defined successful early EN advancement as initiation within 48 hours and no reduction or discontinuation for 7 days
  • Used a two-stage multivariable logistic regression approach to identify predictors of early EN initiation and advancement.
  • 722 patients (34.2%) achieved early EN initiation, with 449 (62.2%) reaching successful advancement, representing 21.3% of the total cohort
  • Significant negative predictors included male sex (aOR 0.87, 95% CI 0.78–0.96), higher admission lactate (aOR 0.85, 95% CI 0.74–0.96), prior surgery (aOR 0.81, 95% CI 0.70–0.93), and higher APACHE II score (aOR 0.88, 95% CI 0.79–0.99)

Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/6a362fe6db0793dc1a5373e5https://doi.org/10.3390/nu18121977
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapid advancement of enteral nutrition and in‐hospital mortality in critically ill adults: A retrospective cohort study2024 · 1 citations
  2. 2The impact of timing of enteral nutrition initiation on the prognosis of abdominal infection in critically ill patients2025
  3. 3Effects of enteral nutrition initiation time and nutritional adequacy on the prognosis of critically ill adults: systematic review and meta-analysis2026
  4. 4Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study2024
  5. 5Early versus delayed enteral nutrition in ICU patients with sepsis: a propensity score-matched analysis based on the MIMIC-IV database2024 · 8 citations