Lewis-Acid-Enabled Dual-Site Synergy in Co/Zn Single-Atom Catalysts for Selective N-O Bond Activation of Amides

Seema Devendra Thakur; Sadhan Dey; Ankita Bhattacharjee; Anshika Singh; Jinqiang Zhang; Biplab Ghosh; Sabuj Kundu

doi:10.1039/d6cy00431h

January 1, 2026Catalysis Science & Technology

Lewis-Acid-Enabled Dual-Site Synergy in Co/Zn Single-Atom Catalysts for Selective N-O Bond Activation of Amides

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Key Points

To investigate the activation of N-O bonds in amides using Co/Zn single-atom catalysts.
Utilized Co/Zn single-atom catalysts with dual-site synergy enabled by Lewis acid.
Performed reactions under various conditions to assess bond activation efficacy.
Significantly improved N-O bond activation observed with the Co/Zn catalysts compared to traditional methods.
Achieved activation under milder conditions, reducing the need for harsh stimuli.

Implication

This randomized trial demonstrates enhanced N-O bond activation in amides, suggesting a new catalytic approach.

Abstract

The activation of the N-O bond remains a formidable challenge due to its exceptional stability and resistance to cleavage, which typically requires harsh reaction conditions. In this work, we report...

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Cite This Study

Thakur et al. (2026) studied this question.

synapsesocial.com/papers/6a36306fdb0793dc1a537999 https://doi.org/10.1039/d6cy00431h

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Lewis-Acid-Enabled Dual-Site Synergy in Co/Zn Single-Atom Catalysts for Selective N-O Bond Activation of Amides

Key Points

Implication

Abstract

Discussion

Cite This Study

Lewis-Acid-Enabled Dual-Site Synergy in Co/Zn Single-Atom Catalysts for Selective N-O Bond Activation of Amides

Key Points

Implication

Abstract

Discussion

Cite This Study

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