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June 20, 2026Acta chimica slovenicaOpen Access

N’-(2-Hydroxy-4-methoxybenzylidene)-4- methylbenzohydrazide and its dinuclear nickel(II) and cadmium(II) complexes: Synthesis, crystal structures and urease inhibition

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Authors

CL Chi LiuLCLiu-Xiu ChenZHZi-Fu Hu

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Overview

Randomized trial identifies urease inhibition in metal complexes, implying potential for drug development.

Key Points

  • To investigate the synthesis and urease inhibitory activities of a hydrazone compound and its metal complexes.
  • Synthesis of N’-(2-Hydroxy-4-methoxybenzylidene)-4-methylbenzohydrazide and its nickel(II) and cadmium(II) complexes.
  • Characterization through elemental analysis, infrared/electronic spectroscopy, and single crystal X-ray determination.
  • Urease inhibitory assay to measure IC50 values for hydrazone and its complexes.
  • The IC50 for complex 1 (nickel) is 18.2 ± 1.1 μmol L–1, indicating moderate activity.
  • The IC50 for complex 2 (cadmium) is 0.38 ± 0.12 μmol L–1, showing strong inhibition.
  • Both complexes exhibit higher urease inhibitory activity compared to the standard drug acetohydroxamic acid (IC50 = 28.1 μmol L–1).

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a36309edb0793dc1a537b34https://doi.org/10.17344/acsi.2026.9766
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