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June 20, 2026Journal of Hepatocellular CarcinomaOpen Access

Putative Imprinting Control Regions with Aberrant Blood-Based DNA Methylation are Associated with Hepatocellular Carcinoma Risk

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Authors

ADAnnie J DiFrankBCBruce A. CorlissJPJames J.H. Park

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Overview

Randomized trial identifies aberrant DNA methylation associated with hepatocellular carcinoma, suggesting biomarkers for earlier detection.

Key Points

  • This study aims to find specific regions of DNA methylation in blood that are linked to the risk of hepatocellular carcinoma.
  • Performed whole genome bisulfite sequencing on leukocyte-derived DNA from 10 primary HCC cases and 51 controls.
  • Validated findings with an independent comparison of 29 primary HCC cases and 36 controls using a Human Imprintome Methylation Array.
  • Identified differential methylation and established associations with hepatocellular carcinoma.
  • Identified 1,519 differentially methylated regions associated with HCC (FDR p < 0.05) linked to 81 putative ICRs.
  • Replicated 46 of these regions (57%) using validation methods (FDR p < 0.05).
  • Enrichment of nearest genes in pathways related to liver disease including hyperplasia, hepatitis, steatosis, and HCC.

Cite This Study

DiFrank et al. (2026) studied this question.

synapsesocial.com/papers/6a3630f5db0793dc1a537fa3https://doi.org/10.2147/jhc.s605131
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