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June 20, 2026Nature CommunicationsOpen Access

Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer

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Authors

SWSirui WengThe University of MelbourneLCLachlan CainPeter MacCallum Cancer CentreJCJames CombenThe University of Melbourne

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Implication

Randomized trial examines intra-tumour heterogeneity in metastatic prostate cancer, indicating key targets for treatment.

Key Points

  • This research aims to understand the mechanisms driving metastatic heterogeneity in late-stage prostate cancer.
  • Utilized single-cell multi-omics and whole-genome sequencing.
  • Profiled 34 metastatic lesions from 9 patients via rapid autopsy.
  • Focused on metastatic castration-resistant prostate cancer.
  • Identified recurrent tumour populations as key functional components across metastatic lesions.
  • Found little evidence of microenvironment-induced transcriptional changes, emphasizing clonal evolution's role.
  • Revealed that intra-patient functional convergence indicates selection pressures driving heterogeneity.

Cite This Study

Weng et al. (2026) studied this question.

synapsesocial.com/papers/6a363123db0793dc1a53812chttps://doi.org/10.1038/s41467-026-74334-z
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