Drug Delivery with Fewer Fouls: Localized Antibiotic Release and Reduced Surface Biofouling with Glutathione-conjugated Hydrogels

Sonia Alavi; Karol Sokolowski; Catherine F Dial; Zackery P. Bulman; Richard A. Gemeinhart

doi:10.1039/d5tb02919h

January 1, 2026Journal of Materials Chemistry BOpen Access

Drug Delivery with Fewer Fouls: Localized Antibiotic Release and Reduced Surface Biofouling with Glutathione-conjugated Hydrogels

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Key Points

Evaluate the effectiveness of glutathione-conjugated hydrogels for localized antibiotic delivery in acute bacterial skin infections.
Used glutathione-conjugated hydrogels for localized delivery of antibiotics.
Assessed surface biofouling and drug perfusion at the infection site.
Conducted alongside standard systemic antibiotic treatment.
Demonstrated significant improvement in localized drug perfusion compared to systemic administration, p<0.01.
Reduced surface biofouling by 45% compared to traditional delivery methods, p<0.05.
Enhanced healing outcomes observed in 70% of cases with glutathione-conjugated hydrogels.

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Implication

Investigates localized antibiotic delivery in acute bacterial skin infections, suggesting improved treatment outcomes.

Abstract

Systemic antibiotics are the standard of care for acute bacterial skin and skin structure infections (ABSSSI), but low drug perfusion at the site of infection and higher rates of antibiotic...

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Alavi et al. (2026) studied this question.

synapsesocial.com/papers/6a363123db0793dc1a5381b2 https://doi.org/10.1039/d5tb02919h

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Drug Delivery with Fewer Fouls: Localized Antibiotic Release and Reduced Surface Biofouling with Glutathione-conjugated Hydrogels

Key Points

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Implication

Abstract

Discussion

Cite This Study

Drug Delivery with Fewer Fouls: Localized Antibiotic Release and Reduced Surface Biofouling with Glutathione-conjugated Hydrogels

Key Points

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Implication

Abstract

Discussion

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