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Investigates cocarcinogenic effects in mice, suggesting specific agents enhance tumor formation.
Summary Five cigarette smoke components were tested for cocarcinogenic activity; they were repeatedly applied to mouse skin together with a low dose of benzo[a]pyrene for 52 weeks. Pronounced activity was shown by catechol and the noncarcinogenic aromatic hydrocarbons pyrene, benzo[e]pyrene, and benzo[g,h,i]perylene. Phenol had a small inhibitory effect on benzolalpyrene tumorigenesis.
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Duuren et al. (1973) studied this question.
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