What question did this study set out to answer?

This study aims to validate the clinical performance of the meSDC2 stool test for detecting colorectal cancer.

June 20, 2026DiagnosticsOpen Access

A Validation Study of Methylated Syndecan-2 in Stool DNA for the Detection of Colorectal Cancer

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Authors

HCHyoung Il ChoiKyung Hee University Hospital at Gangdong YHYoon Dae HanYonsei University JMJae MyungKyung Hee University Hospital at Gangdong

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Implication

Validation study demonstrates high sensitivity and specificity of meSDC2 for colorectal cancer detection in a multicenter hospital setting, suggesting its clinical utility.

Key Points

This study aims to validate the clinical performance of the meSDC2 stool test for detecting colorectal cancer.
Prospective, retrospective, multicenter, single-blind, case-control design.
Conducted at three tertiary medical centers with 636 participants.
Endpoints included sensitivity, specificity, and performance by tumor stage and lesion type.
Sensitivity of the meSDC2 test for CRC was 87.7% (95% CI: 83.7–91.7%) and specificity was 86.2% (95% CI: 82.7–89.7%).
The meSDC2 test showed higher sensitivity than the fecal immunochemical test (FIT) especially for early-stage CRC (p = 0.037).
Combined testing improved sensitivity to 95.6% with 82.4% specificity.

Cite This Study

Choi et al. (2026) studied this question.

synapsesocial.com/papers/6a363172db0793dc1a5385a7 https://doi.org/10.3390/diagnostics16121901

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Implication

Validation study demonstrates high sensitivity and specificity of meSDC2 for colorectal cancer detection in a multicenter hospital setting, suggesting its clinical utility.

A Validation Study of Methylated Syndecan-2 in Stool DNA for the Detection of Colorectal Cancer

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Cite This Study

A Validation Study of Methylated Syndecan-2 in Stool DNA for the Detection of Colorectal Cancer

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