Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026Pediatric Pulmonology

The Relationship Between Structural and Functional Pulmonary Status and Quality of Life in Children With Primary Ciliary Dyskinesia

View Full Paper
Ask AI
Bookmark
Share

Authors

NSNesibe Hatun SarıhanSOSinem Can OksaySBSabriye Gülçin Bozbeyoğlu

Discussion

Loading...

Member takes

Overview

Randomized trial examines lung function and quality of life in children with primary ciliary dyskinesia, indicating a close relationship between pulmonary health and daily living quality.

Key Points

  • This study investigates how lung function and structural lung changes relate to quality of life in children with primary ciliary dyskinesia (PCD).
  • Evaluated 30 genetically confirmed PCD patients with no active infections.
  • Conducted pulmonary function tests including spirometry, plethysmography, and diffusion capacity.
  • Assessed lung structure using high-resolution CT scans and evaluated quality of life through the St. George's Respiratory Questionnaire.
  • Median FEV1 z-score was -1.6, with 48% showing mild obstruction and 20% severe.
  • CT scans revealed mild lung damage in 80% of patients; quality of life scores fluctuated with lung function impairments.
  • Positive correlation of SGRQ scores with exacerbations, indicating decreased quality of life due to frequent respiratory issues.

Cite This Study

Sarıhan et al. (2026) studied this question.

synapsesocial.com/papers/6a363172db0793dc1a538627https://doi.org/10.1002/ppul.71705
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Airway Disease Progression on Chest Computed Tomography in Children With Primary Ciliary Dyskinesia2025 · 6 citations
  2. 2Associations between respiratory pathogens and lung function in primary ciliary dyskinesia: cross-sectional analysis from the PROVALF-PCD cohort2024 · 18 citations
  3. 3Primary Ciliary Dyskinesia: Insights from a Portuguese tertiary centre cohort2026
  4. 4Early Life Disease Burden and Outcomes in Children Diagnosed With Primary Ciliary Dyskinesia in Infancy2026
  5. 5Structure and function imaging in Primary ciliary dyskinesia: cross-sectional study with <sup>129</sup> Xe ventilation / <sup>1</sup> H anatomical MRI2026 · 1 citations