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June 20, 2026Annals of MedicineOpen Access

Comparing the efficacy and safety of unilateral versus bilateral spinal anesthesia: a meta-analysis and systematic review

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This review evaluates the efficacy and safety of unilateral versus bilateral spinal anesthesia in surgical patients.
Systematic review and meta-analysis of randomized controlled trials (RCTs)
Included studies focused on adults undergoing surgery under spinal anesthesia
Data sourced from PubMed, EMBASE, and Cochrane Library up to December 2024.
Unilateral spinal anesthesia shows longer onset of sensory blockade (MD = 2.58, p = 0.002)
Unilateral spinal anesthesia significantly reduces hypotension incidence (RR = 0.40, p < 0.0001)
No significant differences in bradycardia or urinary retention between the types.

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Randomized trial compares efficacy and safety of unilateral and bilateral spinal anesthesia, suggesting improved safety with unilateral approach.

Wan et al. (2026) studied this question.

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Randomized trial compares efficacy and safety of unilateral and bilateral spinal anesthesia, suggesting improved safety with unilateral approach.