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June 20, 2026Journal of the American Chemical Society

Precision Oligo(ethylene glycol) Interfaces Shape Nanoparticle Biodistribution through In Vivo Protein Corona

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Authors

MHMingxuan HouMCMinglong ChenJCJie Cen

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Overview

Randomized trial demonstrates how engineered nanoparticle surfaces affect organ-level biodistribution, suggesting new strategies in nanomedicine.

Key Points

  • The research aims to investigate how the surface chemistry of nanoparticles influences their biodistribution in the body through protein corona formation.
  • Constructed uniform nanoparticle interfaces using precision oligo(ethylene glycol) ligands.
  • Utilized Co-doped Fe3O4 nanoparticles and magnetic-assisted sorting to analyze protein coronas in vivo.
  • Combined quantitative proteomics and genetic ablation to link protein corona composition with organ distribution.
  • A simplified four-protein corona (ApoE, ApoA-I, C3, C1qA) correlated with organ uptake patterns.
  • Structural changes in coronas were linked to distribution shifts under pathological conditions.
  • Identified key corona proteins that partly explain biodistribution differences in vivo.

Cite This Study

Hou et al. (2026) studied this question.

synapsesocial.com/papers/6a3631fbdb0793dc1a538ba8https://doi.org/10.1021/jacs.6c06399
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Also Consider

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  1. 1Multidimensional Protein Corona Analysis Toward Predictive Nano‐Bio Interface Design2026
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