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June 20, 2026Journal of Hepatocellular CarcinomaOpen Access

Current Status and Emerging Trends in Global Research on Liposome Therapy for Hepatocellular Carcinoma: A Bibliometric Analysis

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Authors

XHXiaotao HongYWYibo WuXWXiaocong Wu

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Overview

Bibliometric analysis reveals research trends and hotspots in liposome therapy for hepatocellular carcinoma, indicating a translational gap.

Key Points

  • This analysis aims to evaluate global research trends and hotspots in liposome therapy for hepatocellular carcinoma (HCC).
  • Analyzed 1116 publications on liposome-based therapy for liver cancer from the Web of Science Core Collection and PubMed.
  • Utilized CiteSpace and VOSviewer for bibliometric analysis to identify trends and research hotspots.
  • Reviewed clinical trial literature to assess progress in clinical applications of liposome therapy for HCC.
  • China led in publication output, with significant contributions from the Chinese Academy of Sciences.
  • Doxorubicin-loaded liposomes, apoptosis, and metastasis emerged as major research hotspots based on keyword analysis.
  • Clinical studies mainly focused on liposomal drug combinations with radiofrequency ablation, showing that advanced clinical translation remains limited.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/6a363274db0793dc1a53902bhttps://doi.org/10.2147/jhc.s608648
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