What question did this study set out to answer?

The aim is to assess the association of IgG N-glycosylation patterns with clinical outcomes in critically ill patients.

June 20, 2026Scientific ReportsOpen Access

Characterization of IgG N-glycan patterns in COVID-19, sepsis and healthy subjects

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial evaluates IgG N-glycan patterns in ICU patients, suggesting infection severity indicators.

The aim is to assess the association of IgG N-glycosylation patterns with clinical outcomes in critically ill patients.
Characterized IgG N-glycans using hydrophilic interaction liquid chromatography (HILIC) and mass spectrometry.
Included healthy controls and ICU patients with COVID-19 or sepsis, stratified by survival outcomes.
Analyzed distinct N-glycan structures and their relative abundances in serum samples.
Identified specific IgG N-glycan patterns associated with sepsis versus COVID-19.
Established correlations between IgG glycosylation and patient outcomes in the COVID-19 group.
Suggests the potential of IgG glycosylation profiling as a prognostic biomarker for disease severity.

Paredes-Orejudo et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark