Adenoid Cystic Carcinoma with Solid-basaloid Features in a Young Woman: Diagnostic, Therapeutic, and Literature-based Insights from a Rare Case

Adenoid cystic carcinoma (AdCC) of the breast is a rare subtype of triple-negative breast cancer, accounting for <0.1% of all breast malignancies. The solid-basaloid variant (SB-AdCC), characterized by comparatively more aggressive histopathological features, is even less common. We report a 24-year-old woman diagnosed with multifocal breast AdCC with solid-basaloid features. She underwent breast-conserving surgery with wire-guided wide local excision and therapeutic reduction mammoplasty, along with sentinel lymph node biopsy, followed by margin re-excision. Adjuvant radiotherapy was administered. At 12 months of follow-up, she remains clinically and radiologically free of detectable disease. This report contextualizes diagnostic, therapeutic, and prognostic considerations in this rare presentation by integrating current literature and molecular insights.