What question did this study set out to answer?

To investigate the correlation between serum and urinary vitamin D metabolites and their relationship with parathyroid hormone levels.

June 20, 2026Bioscience ReportsOpen Access

Evaluation of correlations between serum and urinary vitamin D metabolites using LC-MS/MS

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Randomized trial evaluates urinary vitamin D metabolites as non-invasive indicators of serum levels, suggesting broader applicability.

To investigate the correlation between serum and urinary vitamin D metabolites and their relationship with parathyroid hormone levels.
Used residual serum and urine from health check-ups (n=506) at Shinshu University Hospital, Japan.
Samples underwent solid-phase extraction and LC-MS/MS quantification of vitamin D metabolites.
Correlations between urinary metabolites and serum levels were assessed alongside parathyroid hormone measurements.
Urinary 24,25(OH)2D3 and 23,25(OH)2D3 correlated strongly with serum 25(OH)D (all ρ > 0.7, p < 0.001).
Urinary metabolites exhibited stronger inverse correlations with parathyroid hormone than serum 25(OH)D (ρ = -0.297 to -0.308; all p < 0.001).
Suggests urinary metabolites are potential non-invasive markers of vitamin D status.

Wu et al. (2026) studied this question.

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