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Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches

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This review aims to analyze the pathophysiological mechanisms and therapeutic approaches for Crohn's disease.
Comprehensive analysis of disease mechanisms involving epithelial cells, immune responses, and microbiota.
Utilization of advanced models like organoids and patient-derived xenografts for understanding CD.
Evaluation of diagnostic advancements and therapeutic strategies targeting cytokines, JAK inhibitors, and microbiome.
Highlighted the role of genetic susceptibilities (e.g., NOD2, ATG16L1) and dysregulated T-cell signaling in CD.
Discussed therapeutic approaches including biologics and JAK inhibitors that target inflammatory pathways.
Emphasized the need for personalized interventions based on immunological profiling and microbiota composition.

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Review reveals pathophysiological mechanisms and therapeutic strategies in Crohn's disease, indicating promising personalized interventions.

Jia et al. (2026) studied this question.

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Review reveals pathophysiological mechanisms and therapeutic strategies in Crohn's disease, indicating promising personalized interventions.