Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026

The Warburg effect provides attributes that facilitate tumor-cell resistance.

View Full Paper
Ask AI
Bookmark
Share

Authors

ZZZhining ZhangTMTakumi MikawaMLMatilde E. Lleonart

Discussion

Loading...

Member takes

Overview

Review outlines how aerobic glycolysis and glycolytic enzymes contribute to cancer therapy resistance, suggesting new treatment strategies.

Key Points

  • This review aims to summarize how the Warburg effect and its associated pathways enhance tumor resistance to therapies.
  • Comprehensive review of evidence linking aerobic glycolysis, lactate metabolism, and pentose phosphate pathway to cancer treatment resistance.
  • Focus on the non-metabolic roles of glycolytic enzymes in regulating apoptosis and cell signaling.
  • Discussion of targeted therapies that could counteract drug resistance.
  • Enhanced glycolytic flux facilitates rapid ATP and metabolic precursor generation essential for tumor survival.
  • Non-enzymatic functions of glycolytic enzymes are linked to drug resistance mechanisms, affecting apoptosis and tumor invassiveness.
  • Targeting glucose metabolism may improve the effectiveness of existing cancer therapies.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a3632a0db0793dc1a5392c8https://doi.org/10.14670/hh-25-109
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Warburg effect and beyond: Glycolytic reprogramming in cancer progression and emerging therapeutic strategies2026 · 3 citations
  2. 2Exploiting the Warburg Effect: A Potential Ally for Cancer Treatment2026
  3. 3Targeting the Warburg Effect in Cancer: Where Do We Stand?2024 · 233 citations
  4. 4Targeting the glycolytic switch in cancer: mechanisms, cancer progression and therapeutic challenges2025
  5. 5Glycolytic Signaling Pathways and Anti‐Glycolytic Therapy for Cancer: Research and Perspectives2026