Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026ReceptorsOpen Access

The Dopamine D3 Receptor as an Emerging Therapeutic Target in Parkinson’s Disease: Structural Advances, Signaling Bias and Neuroprotective Perspectives

View Full Paper
Ask AI
Bookmark
Share

Authors

FPFelipe PatricioEDEliud Morales DávilaAPAleidy Patricio-Martínez

Discussion

Loading...

Member takes

Overview

Review discusses dopamine D3 receptor signaling in Parkinson’s disease, highlighting therapeutic implications for treatment.

Key Points

  • Investigate the functional role of the dopamine D3 receptor in Parkinson’s disease and its potential as a therapeutic target.
  • Review of recent structural biology advances for D3R and D2R receptors
  • Analysis of ligand-dependent biased signaling and neuronal resilience studies
  • Discussion of preclinical evidence regarding D3R's impact on synaptic plasticity
  • Recent findings show D3R subtypes have unique roles in non-motor symptoms of PD
  • Biased signaling may allow for targeted modulation of dopaminergic circuits
  • D3R strategies offer the potential for better long-term treatment options, although not yet disease-modifying.

Cite This Study

Patricio et al. (2026) studied this question.

synapsesocial.com/papers/6a3632a0db0793dc1a539388https://doi.org/10.3390/receptors5020021
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Dopamine Receptor 3 in Neuropsychiatric Disorders: A Brief Narrative Review2026 · 1 citations
  2. 2Biased Signaling Agonists Promote Distinct Phosphorylation and Conformational States of the Dopamine D3 Receptor2024 · 1 citations
  3. 3Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators2025 · 2 citations
  4. 4A Ligand-Triggered Receptor Conformation Enables the Design of Selective Agonists for the Dopamine 3 Receptor (D <sub>3</sub> R) Using a Bitopic Strategy2026 · 1 citations
  5. 5Gαo/z-biased coupling profile of the dopamine D3 receptor2026