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June 20, 2026BMC NeuroscienceOpen Access

Age-related susceptibility to paraquat-induced neurotoxicity in male wistar rats: effects on neurobehaviour, substantia nigra cytoarchitecture, and alpha-synuclein levels

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Authors

KIKelechi IchieNnamdi Azikiwe UniversityAAAzuoma AsomughaNnamdi Azikiwe UniversityIOIzuchukwu OkaforUniversity of Ibadan

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Overview

Randomized trial investigates age effects on neurotoxicity in male rats, indicating adult vulnerability to lesions.

Key Points

  • This study aims to explore how different ages affect susceptibility to paraquat-induced neurotoxicity in male Wistar rats.
  • Sixty-three male Wistar rats were categorized into juvenile, young adult, and adult groups, subdivided into treatment categories.
  • Paraquat (10 mg/kg) was administered twice weekly for three weeks, followed by a two-month recovery for some groups.
  • Neurobehavioural assessments and alpha-synuclein quantification via ELISA were performed, along with histological examinations of the substantia nigra.
  • Adult rats showed reduced locomotor activity post-exposure (p=0.020) and more significant histopathological changes compared to younger groups.
  • Recovery after paraquat withdrawal revealed persistent tissue architecture alterations in adults.
  • Serum alpha-synuclein levels decreased only in recovering young-adult animals (p=0.039), showing inconsistencies across age cohorts.

Cite This Study

Ichie et al. (2026) studied this question.

synapsesocial.com/papers/6a3632d2db0793dc1a539440https://doi.org/10.1186/s12868-026-01019-0
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