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June 20, 2026Head & Neck

Current State and Future of Systemic Treatment for Elderly Patients With Head and Neck Cancer Undergoing Radiotherapy

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Authors

PZPardis ZamaniMotamed Cancer InstituteEBErfan BarootchiMotamed Cancer InstituteRARomina AbyanehTehran University of Medical Sciences

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Implication

Review assesses systemic treatments for elderly head and neck cancer patients, indicating effective therapies and the need for tailored assessments.

Key Points

  • This review aims to evaluate systemic treatment options for elderly patients with head and neck squamous cell carcinoma receiving radiotherapy.
  • Reviewed 35 studies from major databases using keywords related to elderly patients and HNSCC.
  • Included studies of patients aged 65+ with HNSCC receiving definitive or adjuvant radiotherapy with systemic treatments.
  • Concurrent chemoradiation improved survival in fit elderly patients, with cisplatin-based CRT being most effective (specific data not provided).
  • For unfit patients, cetuximab and carboplatin have varying results, suggesting the need for alternative approaches.
  • Adding immune checkpoint inhibitors appears feasible and safe, although further research on efficacy and biomarkers is required.

Cite This Study

Zamani et al. (2026) studied this question.

synapsesocial.com/papers/6a3632d2db0793dc1a539455https://doi.org/10.1002/hed.70357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multi‐agent concurrent chemoradiotherapy for locally advanced head and neck squamous cell cancer in the elderly2011 · 64 citations
  2. 2Avelumab–cetuximab–radiotherapy versus standards of care in locally advanced squamous-cell carcinoma of the head and neck: The safety phase of a randomised phase III trial GORTEC 2017-01 (REACH)2020 · 101 citations
  3. 3The Efficacy and Adverse Events in Patients with Head and Neck Cancer Following Radiotherapy Combined with S-1 Therapy: A Meta-Analysis2021 · 6 citations
  4. 4Geriatric Assessment–Driven Intervention (GAIN) on Chemotherapy-Related Toxic Effects in Older Adults With Cancer2021 · 486 citations
  5. 5Definitive chemoradiotherapy in patients with squamous cell cancers of the head and neck - results from an unselected cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”2020 · 41 citations