Capsule-Based Delivery of Rice Bran Phytochemicals: A Promising Intervention for IBS Management

Introduction: Irritable Bowel Syndrome (IBS) is a prevalent functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. Limitations of conventional therapies have increased interest in plant-based alternatives. Rice bran contains bioactive compounds such as γ-oryzanol and quercetin with antioxidant, anti-inflammatory, and gutmodulating properties. This study aimed to extract, formulate, and evaluate these compounds in capsule form for IBS management. Methods: γ-oryzanol and quercetin were extracted from rice bran using solvent extraction and purified using standard techniques. Quantification was performed using validated analytical methods. The extract was formulated into granules and encapsulated. Pharmaceutical quality evaluation was conducted as per Indian Pharmacopoeia standards, including weight variation, disintegration, dissolution, content uniformity, and stability studies. Results: The formulated capsules complied with pharmacopoeial specifications, demonstrating uniform weight and drug content. Rapid disintegration and complete dissolution were observed, indicating favorable release characteristics. Stability studies confirmed the integrity of the bioactive compounds. Analytical findings revealed significant phenolic content, supporting antioxidant potential relevant to IBS pathophysiology. Discussion: The results suggest that the combination of γ-oryzanol and quercetin offers synergistic effects targeting oxidative stress, inflammation, and gut motility—key factors in IBS. The formulation demonstrated desirable pharmaceutical properties; however, the absence of in vivo and clinical validation limits direct therapeutic claims. Conclusion: Rice bran-derived γ-oryzanol and quercetin capsules represent a promising, standardized nutraceutical approach for the management of IBS. Further large-scale clinical studies are required to confirm efficacy and optimize therapeutic application.