A Novel Nomogram for Predicting Osteoporotic Vertebral Compression Fractures with Hounsfield Unit and Vertebral Bone Quality: A Retrospective Cohort Study
Retrospective study compares Hounsfield unit and vertebral bone quality for predicting fractures, suggesting a nomogram model for screening.
Key Points
The study aims to compare the predictive efficacy of Hounsfield unit (HU) and vertebral bone quality (VBQ) for osteoporotic vertebral compression fractures (OVCFs) and develop a nomogram model.
Retrospective cohort study of 385 hospitalized patients (127 OVCFs, 258 controls) from September 2020 to September 2024.
HU and VBQ derived from PACS; demographic, clinical, and radiological data collected.
Statistical analyses included t-tests, chi-square tests, logistic regression, LASSO regression, and ROC curve analysis.
The OVCF group had significantly higher VBQ and lower HU compared to controls.
ROC analysis indicated higher diagnostic accuracy for HU than VBQ.
A nomogram model based on BMI, HU, and VBQ achieved an AUC of 0.84 (training set) and 0.87 (test set), showing good clinical practicability.