Randomized trial examines structural-functional coupling changes in PTSD, indicating links to molecular features.
Key Points
This research aims to explore unique variations in structural-functional coupling (SFC) in PTSD and their association with molecular and transcriptional features.
Analyzed 61 PTSD patients and 62 trauma-exposed controls using multimodal MRI data.
Compared SFC using eigendecomposition method and correlated it with molecular maps and gene expression.
Conducted enrichment analysis on genes related to SFC variations.
PTSD patients showed lower SFC in default mode network, frontoparietal network, and other areas compared to controls.
Higher SFC was observed in PTSD in specific networks compared to controls.
Correlations were found between SFC alterations and clinical symptom severity.