What question did this study set out to answer?

To synthesize evidence on how mental health conditions impact outcomes in individuals diagnosed with COPD.

Association between mental health and chronic obstructive pulmonary disease (COPD) outcomes: systematic review and meta-analysis

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To synthesize evidence on how mental health conditions impact outcomes in individuals diagnosed with COPD.
Systematic search of MEDLINE, Embase, PubMed, PsycINFO, and CINAHL for studies comparing COPD outcomes in adults with and without mental illnesses.
Inclusion of studies that reported at least one COPD outcome measure comparing the two groups.
Pre-registered protocol following PRISMA guidelines.
Comorbid mental illness linked to lower forced expiratory volume (MD=–2.92%, 95% CI –4.35% to –1.48%), lower diffusing capacity (MD=–3.79%, 95% CI –5.72% to –1.86%), and reduced 6-minute walking test distance (MD=–30.42 m, 95% CI –41.03 to –19.82).
Worse quality of life reported with higher St George’s Respiratory Questionnaire scores (MD=15.23 points, 95% CI 13.25 to 17.22) and COPD Assessment Test (MD=7.28, 95% CI 5.81 to 8.74).
Increased exacerbations (adjusted risk ratio=1.58, 95% CI 1.05 to 2.37) and hospitalisations (adjusted OR=1.61, 95% CI 1.43 to 1.81) noted, with potential increased mortality (adjusted HR=1.34, 95% CI 1.07 to 1.69).

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Systematic review reveals comorbid mental illness worsens COPD outcomes, suggesting need for integrated care.

Alsaab et al. (2026) studied this question.

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