Answers are grounded in this paper and cite their sources.
Demonstrates a new method for synthesizing chromone C-glycosides, suggesting innovative pathways for drug discovery.
We report a palladium-catalyzed Catellani-type ortho -C–H glycosylation strategy that enables modular ipso / ortho difunctionalization of 3-iodochromones, leading to highly functionalized α- C -chromone glycosides. Notable highlights include the use of ipso -Heck and Sonogashira couplings as flexible termination steps, along with a broad substrate scope, good chemoselectivity, step-economy, and scalability. In addition, our study presents a novel library of 2,3-difunctionalized chromone C -glycoside molecular scaffolds, offering significant potential for future drug discovery applications.
No takes yet. Share an insight, caveat, or question.
Chauhan et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: