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June 20, 2026Journal of Clinical ApheresisOpen Access

Variation in Chronic Automated Red Cell Exchange Practices for Sickle Cell Disease: Insights Into Isovolemic Hemodilution Use

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Authors

JJJennifer M. JonesJohns Hopkins UniversityFAFatima AldarweeshUniversity of ChicagoNANicole AquiHospital of the University of Pennsylvania

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Implication

Survey identifies variability in chronic red cell exchange practices among SCD clinicians, highlighting need for standardization.

Key Points

  • The aim is to assess variability in chronic red blood cell exchange practices among SCD care providers, focusing on isovolemic hemodilution.
  • Conducted a 72-item survey of chronic red cell exchange practices among ASFA members
  • Retained one response per institution for analysis, totaling 62 responses
  • Performed descriptive statistical analyses on survey findings.
  • 61% of respondents reported using at least one fixed RCE target such as end hematocrit (40%)
  • 60% of institutions performed isovolemic hemodilution red blood cell exchange (IHD-RCE)
  • Variable practices noted regarding minimum hematocrit and response to adverse effects.

Cite This Study

Jones et al. (2026) studied this question.

synapsesocial.com/papers/6a3632fcdb0793dc1a53972ehttps://doi.org/10.1002/jca.70146
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Benefits of isovolemic hemodilution red cell exchange: Real or imagined?2026 · 1 citations
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  3. 3Abnormal rheology of oxygenated blood in sickle cell anemia1970 · 345 citations
  4. 4Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Ninth Special Issue2023 · 664 citations
  5. 5American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support2020 · 501 citations