A novel antibacterial dental resin composite material with quaternary ammonium salt modified mesoporous silica nanoparticles – an in vitro and in vivo animal study
Randomized trial evaluates antibacterial efficacy and cytocompatibility of a new dental composite, suggesting improved caries resistance.
Key Points
This research aims to evaluate the antibacterial properties and cytocompatibility of a novel dental resin composite modified with quaternary ammonium salt.
In vitro assessment of antibacterial efficacy and cytocompatibility of 10 wt% QA-MSN composite.
In vivo evaluation of the composite in a rat model of secondary caries.
Measurements of biofilm formation, fibroblast proliferation, mechanical properties, and caries progression were conducted.
10QM-Resin achieved a 99.7% antibacterial rate and reduced biofilm formation after 48 hours.
Relative proliferation rates of gingival fibroblasts and dental pulp stem cells were 99.8% and 99.5%, indicating strong cytocompatibility.
In the rat model, 10QM-Resin significantly reduced Keyes' scores and lesion depth, showing effectiveness in inhibiting caries progression.