Outcomes Associated with Mitral Regurgitation Reduction and Myocardial Work After Transcatheter Edge-to-Edge Repair of a Mitral Valve in Dogs

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Myxomatous mitral valve disease (MMVD) with mitral regurgitation (n=10). Intervention: Transcatheter edge-to-edge repair (TEER). Primary outcome: Changes in myocardial work indices (global work index and global work efficiency) after TEER.

Q: What does this research mean for the field?

Transcatheter edge-to-edge repair reduces mitral regurgitation severity in dogs with myxomatous mitral valve disease and improves myocardial work efficiency and constructive work. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Soontaree Petchdee; Xufeng Ying; Suchada Huttayananont; Kotchapol Jaturanratsamee; Chattida Panprom; Wannisa Meepoo; Ratikorn Bootcha

doi:10.3390/vetsci13060597

June 19, 2026Veterinary SciencesOpen Access

Outcomes Associated with Mitral Regurgitation Reduction and Myocardial Work After Transcatheter Edge-to-Edge Repair of a Mitral Valve in Dogs

View Full Paper

Ask AI

Bookmark

Share

Key result

TEER linked to immediate ~25% higher global work index alongside reduced mitral regurgitation.

n=10

Figures

Why the study?

As the goal of transcatheter edge-to-edge repair (TEER) is to minimize mitral regurgitation (MR) severity in dogs with myxomatous mitral valve disease (MMVD), this study aimed to determine the association between reduced MR and changes in myocardial work indices after TEER.

Does transcatheter edge-to-edge repair (TEER) improve myocardial work indices and decrease mitral regurgitation severity in dogs with myxomatous mitral valve disease?

Key Points

To evaluate the association between the reduction of mitral regurgitation severity and alterations in myocardial work indices following transcatheter edge-to-edge repair in dogs.
Enrolled N=10 client-owned dogs with moderate-to-severe mitral regurgitation secondary to myxomatous mitral valve disease undergoing transcatheter edge-to-edge repair under multimodal imaging guidance.
Assessed mitral regurgitation severity, transmitral pressure gradients, cardiac chamber dimensions, and myocardial work indices (GWI, GCW, GWW, GWE) before repair, immediately post-procedure (N=10), and at 2-month follow-up (N=6).
TEER significantly decreased mitral regurgitation severity, increasing global work index from 921.7 ± 168 mmHg% pre-procedure to 1149.3 ± 174 mmHg% immediately post-procedure and increasing global work efficiency from 82% to 90%.
At 2-month follow-up, global work index remained elevated at 1003 mmHg%, global work efficiency was maintained at 89%, and global longitudinal strain adjusted to −20%.
Global longitudinal strain correlated strongly and positively with global work efficiency (r = 0.81, p = 0.001), while mild post-procedural transmitral pressure gradients did not cause clinically significant mitral stenosis.

Study Design

Type

Observational (n=10)

Blinding

Single-blind

Multicenter

No

Structured PICO

Does transcatheter edge-to-edge repair (TEER) improve myocardial work indices and decrease mitral regurgitation severity in dogs with myxomatous mitral valve disease?

P

Population

10 dogs with moderate-to-severe myxomatous mitral valve disease underwent transcatheter edge-to-edge repair to assess changes in myocardial work indices, with up to 2 months of follow-up.

I

Intervention

Transcatheter edge-to-edge repair (TEER) of the mitral valve using transesophageal echocardiography and 3D guidance.

O

Outcome

Association between reduced mitral regurgitation and changes in myocardial work indices (GWI, GCW, GWW, GWE) before and after the procedure.surrogate

Main Result

Absolute Event Rate: 1149.3% vs 921.7%

TEER successfully reduces mitral regurgitation in dogs and leads to significant improvements in myocardial mechanical efficiency, highlighting the potential utility of myocardial work analysis in veterinary interventions.

Limitations

Small sample size
Lack of comprehensive invasive hemodynamic assessment
Myocardial work analysis software not validated in dogs
No systematic quality-of-life evaluations
Survivor bias due to four deaths during follow-up
Significant mortality during follow-up (4 deaths) introducing survivor bias
Hemodynamic evaluation performed mainly via echocardiography without invasive pressure measurements
Myocardial work analysis adapted from human software and not validated in dogs
No long-term follow-up or systematic quality of life evaluations

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

TEER-associated MR reduction improved myocardial work efficiency in dogs; hypothesis-generating and should not yet change practice.

Abstract

Transcatheter edge-to-edge repair (TEER) is a recent minimally invasive method of managing mitral regurgitation (MR) in dogs with myxomatous mitral valve disease (MMVD). As the goal of intervention is to minimize MR severity, this study aimed to determine the association between reduced MR and changes in myocardial work indices after TEER in dogs. Ten client-owned dogs with moderate-to-severe MR were enrolled in the study, and all underwent TEER with multimodal imaging guidance. Myocardial work was analyzed before and after the procedure, and the MR severity, transmitral pressure gradients, left atrial and ventricular measurements, and index of myocardial work (GWI: the total myocardial work during systole; GCW: work contributing to LV ejection; GWW: ineffective work that contributes to no forward displacement; and GWE: ratio of constructive work to total work) were calculated. TEER significantly reduced MR severity in the majority of dogs, and this MR decrease was associated with a greater efficiency of myocardial work, more constructive work, and less wasted energy. No significant negative associations of moderate post-procedure gradients with short-term clinical outcomes emerged. TEER-mediated reduction in MR improves myocardial function in dogs. However, long-term studies are also needed to examine the effects of residual MR and transmitral gradients on cardiac function and clinical outcome.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Petchdee et al. (2026) conducted an observational in Myxomatous mitral valve disease (MMVD) with mitral regurgitation (n=10). Transcatheter edge-to-edge repair (TEER) was evaluated on Changes in myocardial work indices (global work index and global work efficiency) after TEER. Transcatheter edge-to-edge repair effectively reduced mitral regurgitation severity in dogs, which was associated with an immediate improvement in global work index (from 921.7 to 1149.3 mmHg%) and global work efficiency (from 82% to 90%).

synapsesocial.com/papers/6a3721e201fe431c25188943 https://doi.org/10.3390/vetsci13060597

View Full Paper

Ask AI

Bookmark

Share

Outcomes Associated with Mitral Regurgitation Reduction and Myocardial Work After Transcatheter Edge-to-Edge Repair of a Mitral Valve in Dogs

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Outcomes Associated with Mitral Regurgitation Reduction and Myocardial Work After Transcatheter Edge-to-Edge Repair of a Mitral Valve in Dogs

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading