Metabolomics-based biomarkers, including arachidonic acid and sphingosine-1-phosphate, were significantly associated with blood pressure responses to antihypertensive drugs in 5 included studies.
Systematic Review (n=5)
Does pharmacometabolomics identify metabolic biomarkers associated with blood pressure response to antihypertensive drugs in patients with primary hypertension?
Pharmacometabolomics identified 46 specific metabolites associated with blood pressure response to common antihypertensive drugs, highlighting potential pathways for individualized hypertension therapy.
Hypertension remains a prevalent, modifiable risk factor for cardiovascular disease, with many patients failing to achieve optimal blood pressure (BP) control despite existing therapies. Pharmacometabolomics offers promise by identifying metabolic biomarkers linked to drug response and holds potential for individualizing antihypertensive treatment. We conducted a systematic review of studies from 2013 to 2023, screening 2577 articles and including five that investigated metabolomics-based biomarkers for antihypertensive drug response in cases of primary hypertension. In total, 46 metabolites were significantly associated with BP responses to diuretics, beta-blockers, and ACE inhibitors or angiotensin receptor blockers. Key predictive metabolites included arachidonic acid, sphingosine-1-phosphate, 2-oxoglutarate, and arachidonoyl-carnitine, affecting responses across fatty acid metabolism, sphingolipid metabolism, the TCA cycle, and amino acid metabolism. This review highlights the potential of pharmacometabolomics to uncover metabolites and pathways associated with individual BP response to antihypertensive drugs. Further validation in diverse populations, drug classes, and combination treatments is needed.
Borzeshi et al. (Fri,) conducted a systematic review in Primary hypertension (n=5). Metabolomics-based biomarkers was evaluated on Blood pressure responses to antihypertensive drugs. Metabolomics-based biomarkers, including arachidonic acid and sphingosine-1-phosphate, were significantly associated with blood pressure responses to antihypertensive drugs in 5 included studies.
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