The cardioprotective effect persisting during recovery from cold acclimation is mediated by the β₂-adrenoceptor pathway and Akt activation

Cardioprotective effect of cold acclimation and that persisting for 2 wk after recovery engage in different mechanisms. The β 2 -adrenoceptor/G i pathway and Akt are involved only in the mechanism of infarct size-limiting effect occurring during the recovery phase. GSK-3β translocated from the Z-line to the H-zone of sarcomeres by cold acclimation returns back to the original position after the recovery phase. The results provide new insights potentially useful for the development of cardiac therapies.