Does Akt activation preserve cardiac function and prevent injury after transient cardiac ischemia in vivo?
Akt activation provides cardioprotection after transient ischemia by reducing cell death and improving function, highlighting it as a potential therapeutic target.
Akt activation exerts a powerful cardioprotective effect after transient ischemia that probably reflects its ability to both inhibit cardiomyocyte death and improve function of surviving cardiomyocytes. Akt may represent an important nodal target for therapy in ischemic and other heart disease.
Matsui et al. (2001) studied this question.