Key result
AKT acts as a critical mediator of physiological hypertrophy in cardiomyocytes, increasing cell size through the S6 kinase pathway and improving inotropism via regulation of Ca(2+)-handling proteins.
Population
Cardiomyocytes and mice models
Design
Review
Authors
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Supports AKT research in hypertrophy models; leaves open human therapeutic translation.
AKT plays a critical role in cardiomyocyte homeostasis, mediating physiological hypertrophy by increasing cell size and improving contractile function.
Latronico et al. (2004) conducted a review in Physiological hypertrophy. AKT was evaluated. AKT acts as a critical mediator of physiological hypertrophy in cardiomyocytes, increasing cell size through the S6 kinase pathway and improving inotropism via regulation of Ca(2+)-handling proteins.
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