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June 21, 2026Cureus0 citationsOpen Access

Primary Myeloid Sarcoma of the Breast Mimicking Carcinoma with Aberrant PAX5 Expression

Primary Myeloid Sarcoma of the Breast Mimicking Carcinoma: Aberrant Expression of PAX5 and KMT2A::MLLT10 Fusion

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Authors

CBChaimae BekhakhAHAnass HalouiNKNassira Karich

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Overview

Case report highlights diagnostic challenge of myeloid sarcoma in breast, emphasizing histopathology and molecular studies.

Key Points

  • This case aims to illustrate the diagnostic difficulties in identifying primary myeloid sarcoma in breast tissue, particularly when mimicking carcinoma.
  • Histopathological examination of breast masses
  • Immunohistochemical analysis including markers like LCA, MPO, and CD68
  • Molecular analysis for KMT2A::MLLT10 fusion
  • Histopathological findings showed poorly differentiated neoplasm with immature myeloid cells.
  • Immunohistochemistry revealed strong positivity for LCA, MPO, CD68, and aberrant PAX5 expression.
  • Molecular analysis confirmed presence of KMT2A::MLLT10 fusion linking it to monocytic differentiation.

Cite This Study

Bekhakh et al. (2026) studied this question.

synapsesocial.com/papers/6a377f3a24f042ddf4c59da4https://doi.org/10.7759/cureus.111135
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