Optineurin, an autophagy adaptor, stabilizes Rictor to maintain Akt/mTOR signaling and antigen presentation

Rashmi Kadam; Deepak Shukla

doi:10.1080/15548627.2026.2689040

June 18, 2026AutophagyOpen Access

Optineurin, an autophagy adaptor, stabilizes Rictor to maintain Akt/mTOR signaling and antigen presentation

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Key Points

The central aim is to investigate how optineurin affects Rictor stability and its role in Akt/mTOR signaling.
Examined the role of optineurin in Rictor stabilization
Investigated its effects on Akt/mTOR signaling pathways
Analyzed implications for antigen presentation
Optineurin significantly stabilizes Rictor, enhancing mTORC2 activity.
Increased Akt signaling was observed, vital for effective antigen presentation.
Disruption of optineurin led to impaired signaling and decreased antigen presentation efficiency.

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Implication

Demonstrates how optineurin regulates Akt/mTOR signaling in maintaining antigen presentation.

Abstract

: OPTN: Optineurin; mTORC1: mammalian target of rapamycin complex 1; mTORC2: mammalian target of rapamycin complex 1; Rictor: Rapamycin-Insensitive Companion of mTOR.

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Cite This Study

Kadam et al. (2026) studied this question.

synapsesocial.com/papers/6a377f3a24f042ddf4c59e4d https://doi.org/10.1080/15548627.2026.2689040

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Optineurin, an autophagy adaptor, stabilizes Rictor to maintain Akt/mTOR signaling and antigen presentation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Optineurin, an autophagy adaptor, stabilizes Rictor to maintain Akt/mTOR signaling and antigen presentation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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