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June 21, 2026Journal of Hepatocellular CarcinomaOpen Access

Integrating Combination Therapy and Smart Embolic Materials to Overcome the Therapeutic Ceiling of Transarterial Chemoembolization in Hepatocellular Carcinoma

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Authors

YFYantao FuCBChenglin BaiYLYunzhi Ling

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Overview

Review evaluates TACE combinations and smart materials to improve outcomes in hepatocellular carcinoma, suggesting new therapeutic strategies.

Key Points

  • Evaluate the integration of combination therapies and innovative embolic materials to enhance TACE for hepatocellular carcinoma.
  • Systematic review of clinical evidence for TACE-based combinations.
  • Analysis of synergistic mechanisms with systemic and locoregional therapies.
  • Examination of novel embolic materials and their functional designs.
  • Some triplet therapy regimens demonstrated progression-free survival benefits.
  • No overall survival superiority was proven, as evidenced by negative outcomes from the LEAP-012 trial.
  • Available meta-analyses show substantial heterogeneity in TACE protocols and outcome definitions.

Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c5a09dhttps://doi.org/10.2147/jhc.s620956
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recent Advances in Embolic Agents for Transarterial Chemoembolization of Hepatocellular Carcinoma2025
  2. 2Transarterial chemoembolisation-based combination therapy as a potential new standard for intermediate-stage hepatocellular carcinoma in the targeted immunotherapy era2026
  3. 3Advanced Microsphere and Hydrogel Platforms for Precision Interventional Therapy of Hepatocellular Carcinoma2025
  4. 4Advanced Microsphere and Hydrogel Platforms for Precision Interventional Therapy of Hepatocellular Carcinoma2025
  5. 5An all-in-one theranostic platform for enhanced TACE: self-developing embolization with dual-targeted arsenic trioxide delivery2026 · 3 citations