What question did this study set out to answer?

The aim is to advance understanding and diagnosis of chronic graft-versus-host disease in the peripheral nervous system.

June 21, 2026Open Access

Proposal for Diagnostic Criteria for Manifestations of Chronic Graft-versus-Host Disease in Peripheral Nervous System and Muscles

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Randomized trial proposes diagnostic criteria for PNSM-cGVHD, indicating the need for early intervention.

The aim is to advance understanding and diagnosis of chronic graft-versus-host disease in the peripheral nervous system.
Proposed diagnostic criteria were evaluated through a retrospective case series from 2007 to 2022.
Applied a scoring system to classify atypical cGVHD affecting the peripheral nervous system and muscles.
Reviewed cases for neurological symptoms and clinical outcomes following allogeneic stem cell transplantation.
Out of 770 allo-HSCT patients, 15 (1.9%) had PNSM-cGVHD.
Based on the new scoring system, 6 were classified as possible and 9 as probable atypical cGVHD.
11 patients responded to 1st-line therapy, while 12 showed response to immunosuppressive treatment.

Steinberg et al. (2026) studied this question.

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