What question did this study set out to answer?

This study aims to assess the effects of aluminum exposure on oxidative stress and hormone levels, focusing on specific genetic polymorphisms.

Genetic variation of CBS (844ins68) and MTHFR A1298C among aluminum-exposed workers with emphasis on the role of oxidative stress

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Randomized trial evaluates genetic polymorphisms' impact on oxidative stress and hormone levels in aluminum workers, indicating health risks.

This study aims to assess the effects of aluminum exposure on oxidative stress and hormone levels, focusing on specific genetic polymorphisms.
Measured urinary heavy metals in 95 aluminum workers and 90 controls using ICP-MS.
Analyzed serum biomarkers (MT-1, MDA, PTH, free testosterone, TAC) with ELISA methods.
Evaluated CBS (844ins68) and MTHFR A1298C gene polymorphisms via PCR-RFLP.
Serum MT-1 and MDA levels rose significantly, while TAC, free testosterone, and PTH levels decreased.
Wild-type MTHFR A1298C genotype correlates with increased MT-1 and MDA levels and decreased TAC compared to controls.
Heterozygote NI genotype of CBS shows lower TAC levels among aluminum workers compared to controls.

Aziz et al. (2026) studied this question.

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Randomized trial evaluates genetic polymorphisms' impact on oxidative stress and hormone levels in aluminum workers, indicating health risks.