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This research aims to understand the role of NFAT5 in regulating gene expression under normal and hypertonic conditions in mpkCCD cells.

June 21, 2026Physiological ReportsOpen Access

Dissecting hypertonicity‐ and NFAT5 ‐dependent gene expression programs in mpkCCD cells

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This research aims to understand the role of NFAT5 in regulating gene expression under normal and hypertonic conditions in mpkCCD cells.
Functional deletion of NFAT5 in mpkCCD cells
Gene expression profiling under isotonic and hypertonic conditions
Comparison of transcriptomes from NFAT5 knockout mice and control mice
Under hypertonic conditions, gene expression was significantly altered in NFAT5-deficient cells compared to control cells.
NFAT5 target genes such as Aqp2 and Ranbp3l were found to be downregulated in both cell types when exposed to hypertonicity.
Partial overlap was observed in hypertonicity-associated and NFAT5-dependent gene expression patterns.

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Randomized trial reveals gene expression changes under hypertonic conditions in renal cells, suggesting new insights into NFAT5 function.

Engel et al. (2026) studied this question.

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