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June 21, 2026Current ProteomicsOpen Access

A robust gene model developed based on the features of ADME genes for predicting lung adenocarcinoma prognosis

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Authors

HLHui LiHuanggang Normal UniversityYHYing HouHenan University of Science and TechnologyLWLiang WangLishui City People's Hospital

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Implication

Randomized trial evaluates a gene model predicting prognosis in lung adenocarcinoma, indicating significant survival implications.

Key Points

  • This study aims to develop and validate a gene model based on ADME genes to predict prognosis in lung adenocarcinoma (LUAD).
  • Utilized clinical and RNA-seq datasets from public databases to collect 298 ADME genes.
  • Conducted clustering and DEG analysis using the R packages ConsensusClusterPlus, limma, and clusterProfiler.
  • Developed a four-gene RiskScore model through univariate Cox regression and LASSO analyses, validated by qPCR and functional assays.
  • Identified 22 prognostic ADME genes leading to clustering of LUAD patients into two subtypes (C1 and C2) with distinct prognostic outcomes.
  • Developed a RiskScore model indicating significantly worse overall survival for high-risk patients (HR not stated).
  • Low-risk patients exhibited higher immune infiltration and greater potential benefits from immunotherapy.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a377fdd24f042ddf4c5a250https://doi.org/10.1016/j.curpro.2026.100122
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