Case report demonstrates gastrointestinal symptoms in a young man with IgA vasculitis, highlighting a rare presentation.
A 19-year-old man presented with persistent epigastric and left lower quadrant pain. Suspected infectious enteritis was treated conservatively without improvement. Upper gastrointestinal endoscopy on day 7 demonstrated multiple erosions and ulcers in the descending duodenum. Initial biopsy showed only nonspecific inflammation. Serologic testing revealed markedly decreased Factor XIII activity, suggesting vasculitic consumption. On day 12, mild transient purpura appeared on both feet. Retrospective immunohistochemical staining of the duodenal specimens revealed IgA deposition in vascular walls and necrotizing small-vessel vasculitis, confirming IgA vasculitis. Oral prednisolone (40 mg/day) induced rapid remission.
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Nakayama et al. (2026) studied this question.
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