Retrospective analysis reveals ferritin levels do not affect outcomes in allogeneic hematopoietic stem cell transplantation, suggesting further research is needed.
Key Points
The study aimed to evaluate the influence of ferritin levels on outcomes following allogeneic hematopoietic stem cell transplantation.
69 patients undergoing allo-HSCT between 2018 and 2021 were included, with ferritin levels measured at the time of transplantation.
Patients were categorized into two groups based on ferritin levels: <1000 ng/mL and ≥1000 ng/mL.
Median overall survival was 4 months for ferritin levels ≥1000 ng/mL and 8 months for <1000 ng/mL (95% CI: 0-24.2).
No statistically significant effects of ferritin levels on engraftment, febrile neutropenia, transplantation-related mortality, or sinusoidal obstruction syndrome (p>.05).
No significant differences in acute and chronic graft-versus-host disease between ferritin groups (p=0.713 and p=0.999).