Randomized trial evaluates alteplase and methylprednisolone effects on inflammation and circulation in brain-dead donors, suggesting benefits for organ quality.
Key Points
To evaluate the effects of alteplase and methylprednisolone on microcirculation and inflammation in brain-dead donors.
Wistar rats were randomized into four groups: sham, brain-dead, alteplase-treated, and alteplase plus methylprednisolone-treated.
Parameters analyzed included microcirculation perfusion, inflammatory mediators, platelet aggregation, and histology.
The study assessed improvements in mesenteric flow, inflammatory response, and vascular density.
Alteplase treatment improved mesenteric microcirculatory flow and reduced platelet aggregation.
Combined therapy with methylprednisolone reduced IL-6, IL-10, and VEGF levels, enhancing leukocyte-endothelial interactions.
Alteplase did not cause damage to any organs assessed in the study.