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This study aims to examine HIV-1 genotypes, drug resistance rates, and molecular transmission networks in Zhongwei City, China.

June 21, 2026VirusesOpen Access

Acquired HIV–1 Drug Resistance and Molecular Transmission Networks in Zhongwei, Ningxia, China

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This study aims to examine HIV-1 genotypes, drug resistance rates, and molecular transmission networks in Zhongwei City, China.
Retrospective cross-sectional design collecting plasma samples from ART-treated patients with viral load ≥200 copies/mL.
HIV-1 pol was amplified by nested PCR and genotyped using maximum likelihood analysis.
Transmission networks were constructed and analyzed using Cytoscape.
75 sequences were obtained; overall acquired drug resistance rate was 40.00%, primarily associated with NNRTIs (30.67%).
CRF07_BC and CRF01_AE were the major subtypes with higher centrality metrics indicating potential for transmission.
Occupation influenced network enrollment significantly (p ≤ 0.05).

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Retrospective cross-sectional study characterizes HIV-1 genotypes and drug resistance in Zhongwei, indicating new prevention strategies.

Duan et al. (2026) studied this question.

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