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June 21, 2026Mutagenesis

Unveiling the Genotoxic Safety and Antioxidant-Mediated DNA Protective Mechanisms of Triammonium Citrate: An Integrated In Vitro and In Silico Approach

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Authors

EÖEmin ÖztürkHİHasan Basri İla

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Overview

Integrated in vitro and in silico evaluation reveals triammonium citrate's safety and DNA-protective effects, suggesting its bioactive potential.

Key Points

  • This study aims to assess the genotoxic potential and antioxidant properties of triammonium citrate (TAC).
  • Integrated in vitro assays using NIH/3T3 and MCF-7 cells for viability assessment via CCK-8
  • Genotoxicity tests including Ames, chromosomal aberration, micronucleus, and sister chromatid exchange assays in human lymphocytes
  • In silico molecular docking studies to evaluate binding affinities of TAC with DNA replication and metabolic enzymes.
  • Cell viability remained above 90% in all concentrations of TAC (0.25-2 mg/mL)
  • No mutagenic, clastogenic, or aneugenic activities were detected in genotoxicity assays
  • TAC provided up to 96% protection against H₂O₂-induced oxidative damage to DNA.

Cite This Study

Öztürk et al. (2026) studied this question.

synapsesocial.com/papers/6a3780d724f042ddf4c5ad9bhttps://doi.org/10.1093/mutage/geag025
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