INTRODUCTION: Histograms are graphical representations of blood cell populations and offer valuable insights into clinical diagnostics. They play a crucial role in verifying differential cell counts, ensuring quality control, detecting uncommon disease processes, and assessing sample integrity. Abnormalities in histograms and related complete blood cell count (CBC) parameters have been observed in various hematological conditions. These abnormalities can manifest as shifts in cell populations, changes in the size and shape of cells, or the presence of atypical cell types. METHODS: Understanding the potential changes and flags that can occur in CBCs is essential for accurate diagnosis and patient management. RESULTS: Interpreting the derived histogram pattern and combining it with other CBC parameters and peripheral blood film analysis can enhance the evaluation process, leading to more precise and timely clinical decisions. DISCUSSION: This comprehensive article discusses different types of anemia and reviews the associated changes in CBC parameters, histogram patterns, and blood film characteristics. By studying this review, readers will gain the ability to correlate CBC histograms and parameters with microscopic findings, enabling them to interpret and diagnose various anemias with confidence.
Bahmei et al. (Wed,) studied this question.