Formulation and Evaluation of Fusidic Acid Cream for Enhanced Diabetic Wound Healing as Novel Drug Delivery Systems

Background: Fusidic Acid is primarily bacteriostatic and exhibits a spectrum of activity predominantly against Gram-positive bacteria of particular relevance to diabetic wounds is its potent efficacy against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) strains, which are among the most common and problematic pathogens colonizing and infecting these wounds. In the present study that the developed a novel topical cream of Fusidic Acid (FA) to leverage their complementary actions. Methods: The cream was formulated via melt-emulsification and optimized for physicochemical properties (pH, viscosity, spreadability, homogeneity). Compatibility and microbiological sterility were confirmed. Results: The optimized selected Cream Formulation exhibited desirable properties: a skin compatible pH (5.1–6.0), low viscosity with excellent spreadability, homogeneous texture, and no microbial contamination. Conclusion: It was concluded that the best selected Cream Formulation of the Fusidic Acid Cream NDDS was found to be optimized formulation possessed excellent evaluated parameters among the Cream Formulations NDDS. These formulations favorable properties and efficacy indicate it as a promising strategy for improving outcomes in infected diabetic wounds. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the NDDS (Novel Drug Delivery Systems) product development process.