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June 21, 2026Histopathology

The prognostic value of tumour budding for survival in stage II and III colorectal cancer: a systematic review and meta‐analysis

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Authors

YSYao ShuRadboud University NijmegenHZHeng ZhangRadboud University NijmegenALAlessandro LugliUniversity of Bern

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Implication

Systematic review evaluates tumour budding's impact on survival in colorectal cancer, suggesting better risk assessment.

Key Points

  • This study evaluates the prognostic value of high-grade tumour budding in stage II and III colorectal cancer.
  • Conducted a systematic search of PubMed, Embase, and Cochrane Library for related studies.
  • Included 43 studies with 17,831 patients reporting associations between high-grade tumour budding and survival outcomes.
  • Calculated pooled hazard ratios for disease-free survival, overall survival, and cancer-specific survival using random-effects models.
  • High-grade tumour budding was associated with worse disease-free survival (HR 2.53, 95% CI 2.14–3.00).
  • High-grade tumour budding predicted worse overall survival (HR 2.40, 95% CI 1.69–3.42).
  • High-grade tumour budding was significantly linked to worse cancer-specific survival (HR 3.37, 95% CI 2.19–5.19).

Cite This Study

Shu et al. (2026) studied this question.

synapsesocial.com/papers/6a37815a24f042ddf4c5b3f4https://doi.org/10.1111/his.70225
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